Agent	Usual dosage	Side effects of drug interactions
Glucosamine9	1,500 mg per day in three divided doses	Gastrointestinal discomfort*
Chondroitin8	1,200 mg per day in three divided doses	Gastrointestinal discomfort
SAMe17	400 to 1,200 mg per day	Gastrointestinal discomfort, mainly diarrhea
DMSO31	Daily application of 25% topical gel	Skin rash, pruritus
Avocado/soybean unsaponifiables34	300 mg per day	None
Exercise	30 to 60 minutes of low-impact exercise	—