Agent	Indications	Recommended treatment regimen*
Hepatitis B virus (HBV)	ALT level >two times normal Positive for HBV DNA Positive for HBe antigen	Interferon alfa-2b (Intron A)†: 5 million IU SQ or IM daily or 10 million IU SQ or IM three times per week for 16 weeks
			or
		Lamivudine (Epivir-HBV): 100 mg daily for up to one year
			or
		Adefovir dipivoxil (Hepsera): 10 mg daily for up to 48 weeks
Hepatitis C virus (HCV)‡	ALT level >two times normal Positive for HCV RNA Cirrhosis, fibrosis, or inflammation on liver biopsy§	Pegylated interferon alfa-2b (PEG-Intron): 1.5 mcg per kg SQ weekly with ribavirin (Rebetol), 600 mg twice daily, for up to 48 weeks‖
			or
		Pegylated interferon alfa-2a (Pegasys): 180 mcg SQ weekly with ribavirin, 600 mg twice daily, for up to 48 weeks
		Pegylated interferon alfa-2b: 1.5 mcg per kg SQ weekly for up to 48 weeks‖ (if ribavirin is contraindicated)
			or
		Pegylated interferon alfa-2a: 180 mcg SQ weekly for up to 48 weeks (if ribavirin is contraindicated)