Antimicrobial agent		Dosage	Duration of therapy*	Rating of evidence†
Penicillin V‡		Children: 250 mg orally two or three times daily	10 days	A-II
		Adolescents and adults: 250 mg orally three or four times daily	10 days	A-II
		Adolescents and adults: 500 mg orally twice daily	10 days	C-III
Penicillin G benzathine		1.2 × 106 U IM	One dose	A-II§
		6.0 × 105 U IM	One dose‖	A-II
Mixture of penicillin G benzathine and penicillin G procaine		Varies with formulation ¶ given IM	One dose	B-II
For penicillin-allergic patients
	Erythromycin	Varies with formulation#; given orally	10 days	A-II
	First-generation cephalosporin**	Varies with agent; given orally	10 days	A-II