Drug name	FDA pregnancy risk classification by trimester (1st/2nd/3rd)	Drug class	Crosses placenta?	Use in pregnancy
Acetaminophen (Tylenol)	B/B/B	Non-narcotic analgesic/antipyretic	Yes	Pain reliever of choice
Aspirin	D/D/D	Salicylate analgesic/antipyretic	Yes	Not recommended except for specific indications*
Ibuprofen (Advil, Motrin)	B/B/D	NSAID analgesic	Yes	Use with caution; avoid in third trimester†
Ketoprofen (Orudis)	B/B/D	NSAID analgesic	Yes	Use with caution; avoid in third trimester†
Naproxen (Aleve)	B/B/D	NSAID analgesic	Yes	Use with caution; avoid in third trimester†