Drug name	FDA pregnancy risk classification	Drug class	Crosses placenta?	Use in pregnancy
Butoconazole (Femstat)	C	Imidazole antifungal	Not known	Probably safe
Clotrimazole (Lotrimin)	C	Imidazole antifungal	Not known	Safe in second and third trimesters (human trials),24 first trimester probably safe23
Miconazole (Monistat)	C	Imidazole antifungal	Not known	Probably safe
Tioconazole (Vagistat-1)	C	Imidazole antifungal	Not known	No data