Lesion	Location	Characteristics
Cystic lesions
Bartholin's duct cyst	Vestibule	Usually unilateral; asymptomatic if remains small
Epidermal inclusion cyst	Labia majora (usually)	Benign, mobile, nontender; caused by trauma or obstruction of pilosebaceous ducts
Mucous cyst of the vestibule	Labia minora, vestibule, periclitoral area	Soft, less than 2 cm in diameter, smooth surface, superficial location; solitary or multiple; usually asymptomatic
Hidradenoma papilliferum	Between labia majora and labia minora	Benign, slow-growing, small nodule (2 mm to 3 cm); arises from apocrine sweat glands
Cyst of the canal of Nuck	Labia majora, mons pubis	Soft, compressible; peritoneum entrapped within round ligament; may mimic inguinal hernia
Skene's duct cyst	Adjacent to urethral meatus in vestibule	Benign, asymptomatic; if large, may cause urethral obstruction and urinary retention
Solid lesions
Fibroma	Labia majora, perineal body, introitus	Firm, asymptomatic; may develop pedicle; may undergo myxomatous degeneration; potential for malignancy
Lipoma	Labia majora, clitoris	Benign, slow-growing; sessile or pedunculated
Leiomyoma	Labia majora	Rare; solitary, firm; arises from smooth muscle
Acrochordon	Labia majora	Benign, fleshy, variable size; usually pedunculated but may be sessile; polypoid in appearance
Neurofibroma	Multicentric	Small, fleshy; polypoid in appearance; multiple; associated with von Recklinghausen's disease
Angiokeratoma	Multicentric	Rare, benign; vascular; variable size and shape; single or multiple; associated with and aggravated by pregnancy; associated with Fabry's disease
Squamous cell carcinoma	Multicentric	Related to benign epithelial disease in older women and to human papillomavirus infection in young women