Drug	Loading dose	Maintenance dosage	Route of metabolism	Dialyzable (% protein binding)	Adverse effects
Diazepam (Valium)	10 to 20 mg	None	Hepatic	>90	Respiratory depression, hypotension, sialorrhea
Lorazepam (Ativan)	4 mg	None	Hepatic	90	Same as diazepam
Phenytoin (Dilantin)	18 to 20 mg per kg at 50 mg per minute	5 mg per kg per day	Hepatic	70	Cardiac depression, hypotension
Fosphenytoin (Cerebyx)	18 to 20 mg per kg PE at 150 mg per minute	None	Hepatic	70	Cardiac depression, hypotension, paresthesias
Phenobarbital	20 mg per kg	1 to 3 mg per kg per day	Hepatic	50 to 60	Respiratory suppression
Pentobarbital	2 to 8 mg per kg	0.5 to 5 mg per kg per hour	Hepatic	59 to 63	Hypotension, respiratory suppression
Midazolam (Versed)	0.2 mg per kg	0.75 to 10 mg per kg per minute	Hepatic	96	Hypotension, respiratory suppression
Propofol (Diprivan)	2 mg per kg	5 to 10 mg per kg per hour initially, then 1 to 3 mg per kg per hour	Hepatic	97 to 98	Respiratory depression, hypotension, lipemia, acidosis