Condition	Medication and recommended dosages	Efficacy/recommendations	Level of evidence
Generalized anxiety disorder	Fluvoxamine (Luvox), 50 to 300 mg daily3,4	Effective; may be a good long-term alternative to benzodiazepines or other anxiolytics	A: RCT
	Paroxetine (Paxil), 20 to 60 mg daily (generalized anxiety disorder is not an off-label use)5	—	A: RCT
Premature ejaculation	Paroxetine, 20 mg daily or as needed a few hours before anticipated sexual activity6,7	Effective; consider as first-line treatment	A: RCT
	Sertraline (Zoloft), 25 to 50 mg daily or as needed a few hours before anticipated sexual activity6,8,9
	Fluoxetine (Prozac), 20 mg daily6
Migraine headaches (prophylaxis)	Fluoxetine, 20 to 40 mg daily10–12	May be useful if patient cannot use standard prophylactic agents or if other agents fail; good choice if patient has concomitant depression or other illness treatable with SSRI	A: RCT
Diabetic neuropathy	Paroxetine, 40 mg daily13	Possibly effective; other drugs should be considered first. One meta-analysis found no difference between placebo and SSRIs.	B: lower quality RCT
Fibromyalgia	Fluoxetine, 20 mg daily14,15	Possibly effective, particularly when combined with amitriptyline (Elavil)	B: lower quality RCT
	Citalopram (Celexa), 20 to 40 mg daily16,17	Studies on citalopram showed no significance	B: lower quality RCT
Neurocardiogenic syncope	Paroxetine, 20 mg daily18	May be useful if standard treatments fail	A: RCT
	Sertraline, 50 mg daily19	Has been studied in children	B: nonrandomized, small, prospective trial
	Fluoxetine, 20 mg daily20	—	B: nonrandomized, small, prospective trial