Trial		Measure evaluated	Relative risk reduction in eye disease	Relative risk reduction in kidney disease	Relative risk reduction in cardiovascular disease
UK Prospective Diabetes Study16,17		A1C reduction of 0.9%	Retinopathy, 21%	Albuminuria, 33%	Myocardial infarction, 16%
		Blood pressure of 144/82 mm Hg compared with average blood pressure of 154/87 mm Hg	Cataract extraction, 24%	N/A	Stroke, 44%
			Retinopathy progression, 34%		Heart failure, 56%
			Vision deterioration, 47%
Hypertension Optimal Treatment Study18		Diastolic treatment goal: 80 mm Hg	N/A	N/A	Cardiovascular events, 51%
Heart Outcomes Prevention Evaluation Study19		Ramipril in patients with diabetes	N/A	N/A	Stroke, myocardial infarction, or cardiovascular death, 25 to 30%
Captopril Prevention Project20		Captopril in patients with diabetes	N/A	N/A	Cardiovascular death, 48%