Disorders (percentage of all primary immunodeficiencies)			Genetic inheritance pattern	Incidence, if known	Sex affected	Age at diagnosis
Disorders of humoral immunity: B-cell differentiation and antibody production (~ 50)
	Common variable immunodeficiency		Undetermined	One case per 10,000 to 50,000 persons	Both	>2 years; can be in 20s or 30s
	Selective IgA deficiency		Undetermined	About one case per 300 to 700 persons	Both	>4 years
	Bruton's or X-linked agammaglobulinemia		X-linked	Undetermined	Males	>6 months
T-cell defects and combined B-cell and T-cell defects (~30)
	Severe combined immunodeficiency		X-linked	One case per 100,000 to 500,000 persons	Males	<6 months
		T-cell deficient, B-cell competent	Autosomal recessive		Both	<6 months
		T-cell deficient, B-cell deficient	Autosomal recessive		Both	<6 months
	DiGeorge syndrome		Autosomal dominant or spontaneous	Undetermined	Both	<6 months
	Wiskott-Aldrich syndrome		X-linked	Undetermined	Males	<6 months
	Ataxia-telangiectasia		Autosomal recessive	Undetermined	Both	>5 years
	X-linked hyper IgM		X-linked	Undetermined	Males	Variable
Phagocytic disorders (~ 18)
	Chronic granulomatous disease		X-linked (70% of cases) or autosomal recessive (22% of cases)	One case per 200,000 persons	Males > females	Usually <5 years; diagnosis can be in 20s and 30s
Complement disorders (~ 2)
	Complement deficiencies (at least 16 distinct disorders)		Autosomal recessive, autosomal dominant, or X-linked	Undetermined	Both	Any age