Adverse effect	Frequency (%)	Method of diagnosis	Treatment
Serious effects
Pulmonary toxicity	2 to 172	Chest radiograph; pulmonary function tests, including Dlco	Stop amiodarone; initiate corticosteroid therapy.
Hyperthyroidism	22	Free T4 level, TSH level	Initiate antithyroid drug therapy; consider stopping amiodarone.
Hypothyroidism	65	Free T4 level, TSH level	Administer thyroid hormone supplementation.
Liver toxicity	15	Liver enzyme levels three times higher than normal	Consider stopping amiodarone.
Optic neuropathy	Unknown19	Ophthalmologic examination	Consider stopping amiodarone; causal relationship is uncertain.
Proarrhythmia	<111	ECG	Stop amiodarone.
Bradycardia	2 to 42	Physical examination, ECG	If severe, stop amiodarone or insert pacemaker.
Minor effects
Nausea, anorexia	302	History, physical examination	Reduce dosage.
Corneal microdeposits	>902,19	Slit-lamp examination	None
Photosensitivity	4 to 92	History, physical examination	Use sunblock.
Blue discoloration of skin	<92	Physical examination	Reduce dosage.