Hepatitis B surface antigen (HBsAg): present in acute or chronic infection
Hepatitis B surface antibody (anti-HBs): marker of immunity acquired through natural HBV infection, vaccination, or passive antibody (immune globulin)
Hepatitis B core antibody (anti-HBc):
IgM—indicative of infection in the previous six months
IgG—indicative of more distant HBV infection that may have been cleared by the immune system or that may persist; positive HBsAg and anti-HBc IgG—indicative of persistent chronic HBV infection
Hepatitis B e antigen (HBeAg)*: correlates with a high level of viral replication; often called a “marker of infectivity”
Hepatitis B e antibody (anti-HBe): correlates with low rates of viral replication
HBV DNA: correlates with active replication; useful in monitoring response to treatment of HBV infection, especially in HBeAg-negative mutants