Infants and children less than two years of age with known CLD who required medical therapy for CLD within six months of the anticipated start of the RSV season.

Preterm infants born at 28 weeks of estimated gestational age or earlier may benefit from prophylaxis during their first RSV season, whenever that occurs during the first year of life, even if CLD is not present.

Preterm infants born at 29 to 32 weeks of estimated gestational age or earlier may benefit from prophylaxis during their first RSV season, when- ever that occurs during the first six months of life, even if CLD is not present.

Infants born at 32 to 35 weeks of estimated gestational age must have two of the following risk factors to be candidates for prophylaxis: attendance at a child-care center, school-aged siblings, exposure to environmental pollution, abnormalities of the airways, or severe neuromuscular problems.