| Aspirin | 81 to 325 mg per day orally | Recommended by the American College of Chest Physicians for PAD, but the FDA found insufficient evidence to approve labeling for this indication |
| Clopidogrel (Plavix) | 75 mg per day orally | Fewer side effects than aspirin in the CAPRIE trial; significantly less risk for TTP than ticlopidine |
| Pentoxifylline (Trental) | 1.2 g per day orally | May have a small effect on walking ability, but insufficient data to support widespread use |
| Cilostazol (Pletal) | 100 mg twice per day orally | Correct dosing is critical; avoid in patients with heart failure; reduce dosing to 50 mg twice per day in patients taking calcium channel blockers; may cause loose stools and gastric upset |
| Ticlopidine (Ticlid) | 500 mg per day orally | Extensive hemodynamic monitoring for risk of TTP |