Patient meets the following criteria for at least 12 weeks (which need not be consecutive) within the preceding 12 months:

Persistent or recurrent symptoms (pain or discomfort centered in the upper abdomen)

No evidence of organic disease (including on upper endoscopy) that is likely to explain the symptoms

No evidence that dyspepsia is relieved exclusively by defecation or associated with the onset of a change in stool frequency or stool form (i.e., not irritable bowel syndrome)