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Am Fam Physician. 2004;70(2):388

In addition to its irritative symptoms, benign prostatic hypertrophy (BPH) can sometimes lead to recurrent urinary tract infections, incontinence, acute retention, or a need for prostate reduction surgery. Both alpha-adrenergic blockers and finasteride have demonstrated efficacy in reducing symptoms related to BPH. One-year trials combining an alpha blocker and finasteride did not show any benefit superior to single-drug therapy in relief of urinary symptoms. McConnell and coinvestigators report on data from a four-year trial of combination therapy for BPH.

This multicenter trial enrolled 3,047 men over age 50 with an American Urology Association (AUA) score of 8 to 30, indicating mild to moderate obstructive urinary symptoms. More than 17 percent of trial participants were from minority groups. Exclusion criteria for the trial included previous medical or surgical treatment for BPH, blood pressure below 90/70 mm Hg, or a prostate specific antigen (PSA) level higher than 10 ng per mL.

Men were randomly assigned to daily dosing with either finasteride (5 mg), doxazosin (titrated up to 4 to 8 mg, as tolerated), combination therapy with both drugs, or placebo. The men were followed for a mean duration of 4.5 years. The primary outcome measured was clinical progression of BPH, which was defined as an increased AUA score of 4 points or more or a morbid outcome related to BPH, such as urinary retention, incontinence, or urosepsis.

Clinical progression of BPH during the study occurred in 1.5 percent of men taking combination therapy, compared with 4.5 percent of participants taking placebo. Monotherapy with doxazosin was associated with clinical progression in 2.7 percent of subjects, while finasteride alone was associated with progression in 2.9 percent. The need for prostate reduction surgery arose in 0.4 percent of men taking combination therapy, 0.5 percent of those taking finasteride alone, 1.3 percent taking doxazosin monotherapy, and 1.3 percent of men taking placebo.

Small increases in side effects were noted with drug therapy compared with placebo, and the effects were additive with combination therapy. The most common side effects that were significantly higher with doxazosin treatment were dizziness and decreased appetite, while finasteride use was associated with erectile dysfunction and decreased libido.

The authors conclude that combination therapy with doxazosin and finasteride reduces clinical progression of BPH over a four-year time period more than either medication alone.

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