In 2000, an estimated 30.5 percent of adults were obese (i.e., had a body mass index [BMI] greater than 30 kg per m2)1 and 15.5 percent of adolescents were overweight (BMI of 25 to 30 kg per m2).2 Given the medical and psychosocial impact of being overweight, as well as the difficulty in making sustained improvements in diet and physical activity, it is not surprising that patients often turn to over-the-counter (OTC) proprietary weight-loss products containing single or multiple dietary supplements (e.g., herbs, vitamins, minerals, amino acids).
|Key clinical recommendations||Label||References|
|Ephedra is somewhat effective for weight loss, but is unsafe; therefore, use of this supplement should be discouraged.||A||8–11|
|Chitosan and guar gum are ineffective for weight loss, and their use should be discouraged.||A||22,38–40|
|Patients should be cautioned regarding the use of chromium, ginseng, glucomannan, green tea, hydroxycitric acid,l-carnitine, psyllium, pyruvate, St. John’s wort, and conjugated linoleic acid because the evidence regarding their efficacy and safety for weight loss is unclear.||B||14–16,19,20,23–36|
A multi-state survey3 in 1998 found that 7 percent of adults used OTC weight-loss supplements, with the greatest use noted among young obese women (28 percent). Retail sales of weight-loss supplements were estimated to be more than $1.3 billion in 2001.4 Metabolife 356, an ephedra-containing combination supplement, was the top-selling diet supplement with $70 million in sales, representing a 127 percent increase from sales in 2000.4
Possible reasons that patients use dietary supplements for weight loss are summarized in Table 1. These supplements appeal to the desire for a “magic bullet” that is less demanding than special diets and increased physical activity. They are available without a prescription and often advertise remarkable benefits. Patients also may be attracted to them because they are marketed as “natural,” which may be interpreted by some (albeit inaccurately) as an assurance of safety and efficacy.
|Social stigma of obesity|
|Health benefits of weight loss|
|Desire for a “magic bullet” for weight loss|
|Less demanding than accepted lifestyle changes, such as exercise and diet|
|Frustration with previous attempts at dieting and/or exercise|
|Easily available without a prescription|
|More easily accessed than a professional consultation with a physician, nurse, or nutritionist|
|Inflated advertising claims|
|Appeal of a “natural” remedy|
|Perception that natural equals safe|
To help identify patients using these supplements, physicians should ask their overweight and obese patients in a non-judgmental manner questions such as, “Have you tried, or considered trying, special diets, exercise programs, diet pills, herbs, or vitamins for weight loss?” If the ingredients of a patient’s weight-loss product are not evident, an Internet search can rapidly yield a product’s Web site and its labeled components.
To counsel patients appropriately, physicians must be knowledgeable about the efficacy, safety, and quality of common weight-loss supplements. Given that supplement users also may be taking prescription medications,3 the potential for drug/supplement interactions should be considered. Because of the Dietary Supplement Health and Education Act of 1994, manufacturers are not required to provide the U.S. Food and Drug Administration (FDA) with proof of safety and efficacy before marketing supplements. Furthermore, adoption of good manufacturing practices by supplement makers is not currently mandatory. Therefore, product quality (e.g., absence of contamination, accuracy of labeling) is variable and uncertain.
More than 50 individual dietary supplements and 125 proprietary products are listed in the Natural Medicines Comprehensive Database as commonly being used for weight loss.5 Individual supplements found in at least five commercial products (Table 25, 6 ) are discussed in this review, according to their purported mechanism of action. Of note, approximately one half of the most common individual supplements used in weight-loss products listed in Table 2 have not been studied in randomized controlled trials (RCTs) in humans.
|Increase energy expenditure|
Bitter orange (49)
Country mallow (13)
Yerba maté (9)
Modulate carbohydrate metabolism
Guar gum (10)
Increase fat oxidation or reduce fat synthesis
Hydroxycitric acid (43)
Green tea (42)
Vitamin B5 (18)
Conjugated linoleic acid (7)
|Block dietary fat absorption|
Increase water elimination
St. John’s wort (19)
Miscellaneous or unspecified
Spirulina [also known as blue-green algae] (13)
Apple cider vinegar (7)
Supplements Purported to Increase Energy Expenditure
EPHEDRA ALKALOIDS AND CAFFEINE COMPOUNDS
Ephedra sinica (or Ma huang in Chinese) is a shrub native to China and Mongolia that contains sympathomimetic compounds referred to as ephedra alkaloids. Bitter orange and country mallow contain related chemicals. Ephedra alkaloids commonly are combined with caffeine or botanical sources of caffeine (e.g., guarana, yerba maté) for weight loss.7 A recent meta-analysis8 of RCTs showed a weight loss of 0.9 kg (2 lb) more per month for ephedra-containing supplements compared with placebo. However, no long-term data (i.e., greater than six months) on efficacy were available.
Using adverse event data from 50 trials of ephedra, a 2.2- to 3.6-fold increase in the odds of psychiatric, autonomic, cardiovascular, and gastrointestinal symptoms was estimated.8 Another review9 of adverse events possibly associated with ephedra use included 87 reports to the FDA MedWatch program between June 1997 and March 1999. These reports included episodes of hypertension, arrhythmias, myocardial infarction, stroke, and seizures. Ten events led to death and 13 yielded permanent disability. Of these 23 reports, nine occurred at recommended dosages of ephedra in persons without significant preexisting cardiovascular risk factors.9
Ephedra products comprised only 0.8 percent of all dietary supplement sales in 2001, yet they were responsible for 64 percent of all herb-related adverse events reported to U.S. Poison Control Centers during the same year.10 Although ephedra-caffeine combinations may be effective for modest weight loss, safety issues motivated the FDA to ban their sale in April 2004.11
Supplements Purported to Modulate Carbohydrate Metabolism
CHROMIUM AND GINSENG
Chromium deficiency is associated with hyperglycemia, hyperinsulinemia, hypertriglyceridemia, and low levels of high-density lipoprotein cholesterol. Chromium is thought to play a role in carbohydrate and lipid metabolism, potentially influencing weight and body composition.12 However, data on healthy persons without diabetes do not support this theory, and data on patients with diabetes are inconclusive.13
Most weight-loss supplements use chromium picolinate in daily dosages of 200 to 400 mcg. The results of three RCTs14–16 that studied the role of chromium in obesity did not show any differences in weight loss between the treatment and placebo groups. However, drawing conclusions from these studies is difficult because of their small size (n = 15 to 36). Although short-term trials using chromium picolinate did not report significant adverse effects,17 there are theoretical concerns that this form of chromium could generate free-radical damage.18 Rhabdomyolysis and renal failure, possibly related to ingestion of more than 1,000 mcg daily of chromium picolinate, have been reported.19,20 Because of the lack of large, well-designed studies, the efficacy of chromium for weight loss and its long-term safety profile remain uncertain.
Although preliminary data suggest that ginseng (Panax ginseng) may improve glucose tolerance,21 no RCTs in humans have shown greater weight loss with ginseng compared with placebo.
Supplements Purported to Increase Satiety
GLUCOMANNAN, PSYLLIUM, AND GUAR GUM
Numerous weight-loss products contain sources of soluble fiber, which theoretically could absorb water within the gut, causing increased satiety and lower caloric intake. Fiber also may improve control of diabetes and hyperlipidemia, two common comorbidities in patients with obesity. Examples include guar gum (derived from the Indian cluster bean, Cyamopsis tetragonolobus), glucomannan (Amorphophallus konjac), and psyllium (derived from the seed husk of Plantago psyllium).
Although guar gum is relatively safe, a meta-analysis22 of 11 RCTs of guar gum versus placebo for weight loss showed no benefit. Three RCTs23–25 suggest that glucomannan in dosages of 3 to 4 g per day may be well tolerated and yield modest weight loss. However, these trials were small (n = 20 to 50) and had methodologic limitations. Although psyllium improved glucose and lipid parameters significantly more than placebo in 125 overweight patients with type 2 diabetes, there were no differences in weight loss.26
Supplements Purported to Increase Fat Oxidation or Reduce Fat Synthesis
Hydroxycitric acid (HCA) is derived from the Malabar tamarind tropical fruit (Garcinia cambogia) native to India. HCA has been found to inhibit mitochondrial citrate lyase, leading to decreased acetyl coenzyme A production and decreased fatty acid synthesis.27 A 12-week RCT28 of mildly overweight women (n = 89; mean BMI of 28.6 kg per m2) reported a 1.3 kg (2 lb, 14 oz) greater weight loss in women who received 750 mg of HCA per day versus placebo. In contrast, an RCT29 comparing a different formulation of HCA at 1,500 mg per day and placebo in 135 men and women with a higher average BMI (31.2 kg per m2) showed no differences in BMI or adverse events. Although HCA appears to be well tolerated, the evidence for efficacy currently is contradictory.
CONJUGATED LINOLEIC ACID
Conjugated linoleic acid (CLA) refers to a family of trans-fatty acids that have been found to reduce fat deposition in obese mice, possibly through increased fat oxidation and decreased triglyceride uptake in adipose tissue.30 A 12-week RCT31 of 60 patients using 3.4 to 6.8 g per day of CLA reported no change in BMI. Persons taking CLA reported mild to moderate gastrointestinal symptoms. Currently, no human data support the efficacy of CLA in weight-loss products.
GREEN TEA, LICORICE, PYRUVATE, VITAMIN B5, ANDl-CARNITINE
In one study,32 green tea increased fat oxidation and thermogenesis in 10 patients, but the study was not designed to assess weight loss. Licorice reduced body fat mass without changing BMI in 15 persons of normal weight.33 However, licorice has been reported to cause pseudoaldosteronism, hypertension, and hypokalemia.34 Six weeks of pyruvate, in a dosage of 6 g per day, was associated with a weight loss of 1.2 kg (2 lb, 10 oz), compared with placebo.35 Although vitamin B5 has been postulated to cause weight loss,36 no human trials support this. Similarly, no trials demonstrate thatl-carnitine is effective for weight loss.
Supplements Purported to Block Dietary Fat Absorption
Chitosan, derived from chitin found in crustacean shells, is a positively charged polymer thought to prevent fat absorption by binding negatively charged fat molecules within the intestinal lumen. A meta-analysis37 of five RCTs that evaluated chitosan and placebo for weight loss showed a greater mean weight reduction for chitosan (3.3 kg [7 lb, 4 oz]) over placebo. All of the studies were conducted by the same team of investigators and several methodologic concerns were noted.
Subsequently, three other researchers reported well-designed RCTs38–40 that failed to show any differences in weight loss. Furthermore, healthy persons taking chitosan have not shown clinically significant increases in fecal fat excretion.41 Given the totality of the evidence, chitosan appears to be safe in short-term studies, but is likely ineffective for weight loss.
Supplements Purported to Increase Water Elimination
Dandelion (Taraxacum officinale) appears to have diuretic activity and cascara (Rhamnus purshiana) acts as a laxative.42 Neither of these herbs has been studied specifically for weight loss in humans. Regarding safety, long-term use of these supplements theoretically could cause adverse effects similar to those of conventional diuretics and laxatives (e.g., dehydration, electrolyte abnormalities).43
Other Common Supplements Used for Weight Loss
Although botanical remedies for depression such as St. John’s wort (Hypericum perforatum) often are found in weight-loss products, no data support their role in weight loss. Laminaria (kelp) has not been studied for weight loss. Spirulina (also known as blue-green algae) contains phenylalanine, which is purported to inhibit appetite. In 1981, the FDA declared spirulina ineffective for weight loss,44 and no subsequent studies to the contrary have been published. Guggul (derived from the myrrh tree, Commiphora mukul) and apple cider vinegar, which contains various vitamins and minerals, have not been studied for weight loss.
Advising the Patient About Weight-Loss Supplements
Criteria adapted from a recent review45 can be used to develop clinical recommendations for each supplement. If there is strong evidence for a product’s quality, safety, and efficacy, it may be reasonable to recommend that product and closely monitor the patient. No supplements discussed in this review meet these criteria, however. In contrast, it would be appropriate to discourage use of products when there is strong evidence for lack of quality, safety, or efficacy. For example, use of products that contain ephedra should be actively discouraged because of serious safety concerns. Chitosan appears to be ineffective for weight loss and should also be discouraged. The use of guar gum for weight loss should be discouraged because of its lack of efficacy. For products that do not fall into the categories to recommend or to discourage use because of insufficient or contradictory evidence, physicians should caution their patients about the risks and benefits of using the product given the uncertainty in safety, efficacy, and/or quality control. Chromium, CLA, ginseng, glucomannan, green tea, HCA,l-carnitine, psyllium, pyruvate, and St. John’s wort fall into this category. If a patient chooses to use one of these supplements, the physician should monitor the patient closely for adverse effects as well as benefit.Table 38,13–18,21–26,28,29,31–35,37–41,44,45 summarizes the evidence for quality, safety, and efficacy for each supplement discussed and provides a suggested clinical stance.
|Supplement||Product quality||Product safety||Product efficacy||Clinical stance*|
|Apple cider vinegar||Uncertain||Uncertain||Uncertain†||Caution and monitor|
|Cascara||Present‡||Uncertain||Uncertain†||Caution and monitor|
|Chromium13–18||Present‡||Uncertain||Uncertain§||Caution and monitor|
|Conjugated linoleic acid31||Uncertain||Uncertain||Uncertain§||Caution and monitor|
|Dandelion||Uncertain||Uncertain||Uncertain†||Caution and monitor|
|Ephedra alkaloid–caffeine combinations8||||Uncertain||Absent||Present||Discourage|
|Ginseng21||Uncertain||Uncertain||Uncertain†||Caution and monitor|
|Glucomannan23–25||Uncertain||Present||Uncertain¶||Caution and monitor|
|Green tea32||Uncertain||Present**||Uncertain†||Caution and monitor|
|Guggul||Uncertain||Uncertain||Uncertain†||Caution and monitor|
|Hydroxycitric acid28–29||Uncertain||Uncertain||Uncertain‡‡||Caution and monitor|
|Laminaria||Uncertain||Uncertain||Uncertain||Caution and monitor|
|l-carnitine||Present‡||Present||Uncertain†||Caution and monitor|
|Licorice33–34||Uncertain||Uncertain||Uncertain†||Caution and monitor|
|Psyllium26||Present‡||Present||Uncertain†||Caution and monitor|
|Pyruvate35||Uncertain||Uncertain||Uncertain¶||Caution and monitor|
|Spirulina (also known as blue-green algae)||Uncertain||Uncertain||Absent§§||Discourage|
|St. John’s wort||Uncertain||Uncertain||Uncertain†||Caution and monitor|
|Vitamin B5||Present‡||Present||Uncertain†||Caution and monitor|
For weight-loss supplements not discussed here, several electronic and print resources containing evidence-based reviews of supplement quality, safety, and efficacy can help physicians obtain the relevant information necessary to counsel patients (Table 4).
|Natural Medicines Comprehensive Database (http://www.naturaldatabase.com)|
|Natural Standard (http://www.naturalstandard.com)|
|Fugh-Berman A. The five-minute herb & dietary supplement consult. Philadelphia: Lippincott Williams|
|& Wilkins, 2003.|
|Rotblatt M, Ziment I. Evidence-based herbal medicine. Philadelphia: Lippincott Williams & Wilkins, 2001.|
Patients who use weight-loss supplements may be highly motivated to lose weight, and physicians can try to harness this motivation to encourage more proactive and established approaches to weight loss, such as changes in diet and exercise. Regarding the future use of dietary supplements for weight loss, well-designed RCTs with standardized quality products and increased regulation of the dietary supplement industry are necessary if any of these products are to be recommended as part of a responsible weight-loss program.