Symptoms

Depression

Dizziness or vertigo

Fatigue

Heat sensitivity

Lhermitte’s sign (electrical sensation down the spine on neck flexion)

Numbness, tingling, pain

Urinary bladder dysfunction

Visual impairment (monocular or diplopia)

Weakness

Signs

Action tremor

Decreased perception of pain, vibration, or position

Decreased strength

Hyperreflexia, spasticity, Babinski’s sign

Impaired coordination and balance

Impaired visual acuity or red color perception with optic disc pallor and afferent pupillary defect; disconjugate eye movements

Nystagmus