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Am Fam Physician. 2004;70(11):2081

to the editor: The following errors appear in Table 1 of the article “Insulin Therapy for Type 2 Diabetes: Rescue, Augmentation, and Replacement of Beta-Cell Function.”1

InsulinOnsetPeak (hours)Usual effective duration (hours)Usual maximum duration (hours)Cost*
Bolus or mealtime insulin
Aspart (NovoLog)5 to 10 minutes1 to 33 to 54 to 6$59
Lispro (Humalog)< 15 minutes0.5 to 1.52 to 44 to 659
Regular (Humulin R, Novolin R)30 to 60 minutes2 to 33 to 66 to 1028
Basal insulin
NPH (Humulin N, Novolin N)2 to 4 hours4 to 1010 to 1614 to 1828
Lente (insulin zinc suspension)3 to 4 hours4 to 1212 to 1816 to 20
Ultralente (extended insulin zinc suspension)6 to 10 hoursPeakless18 to 2020 to 2428
Glargine (Lantus)1 hour, 6 minutesPeakless242451
50% NPH/50% regular30 to 60 minutesDual10 to 1614 to 18
70% NPH/30% regular (Humulin R 70/30, Novolin R 70/30)30 to 60 minutesDual10 to 1614 to 1828
75% NPL/25% lispro (Humalog 75/25)< 15 minutesDual10 to 1614 to 1859†
70% APS/30% aspart (NovoLog Mix 70/30)10 to 20 minutes2.4 ± 0.80242459

NovoLog Mix 70/30 is incorrectly identified as “NovoLog 70/30” and is incorrectly described as 70 percent neutral protamine Hagedorn (NPH) insulin and 30 percent aspart. NovoLog Mix 70/30 does not contain NPH insulin, but rather 70 percent insulin aspart (rDNA origin) protamine suspension and 30 percent insulin aspart (rDNA origin) injection. NovoLog Mix 70/30 is a single solution containing a premixed formulation of 70 percent insulin aspart in the crystalline protamine form and 30 percent insulin aspart in the soluble form.

The table states that NovoLog Mix 70/30 has a dual peak. The glucose-lowering effects for this insulin begin as early as 10 to 20 minutes after subcutaneous injection and are maximal at 2.4 ± 0.80 hours; the duration of action may be as long as 24 hours because of the protaminated insulin aspart. However, examination of the pharmacokinetic profile of NovoLog Mix 70/30 reveals only one peak.

editor’s note: The online version of this article has been corrected, and the corrected table is reprinted above.

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