Treatment	Cost per successful treatment course10	Adverse effects and their incidence (%)*	Clearance rate (%)8,11	Risk of recurrence (%)8,9,11–13 †
Cryotherapy	Simple warts: $268 Extensive warts: $415	Pain or blisters at application site (20)	60 to 90	20 to 40
Imiquimod (Aldara)	Simple warts: $607 Extensive warts: $649	Erythema (70); irritation, ulceration, and pain (< 10); burning, erosion, flaking, edema, induration, and pigmentary changes at application site; minimal systemic absorption	30 to 50	15
Interferon (intralesional)	Simple warts: $2,744 Extensive warts: $5,803	Burning, itching, and irritation at injection site; systemic myalgias, headaches, fever, chills, leukopenia, elevated transaminase levels (6), thrombocytopenia (1)	20 to 60	‡
Laser treatment	Simple warts: $197 Extensive warts: $535	Similar to surgical excision; risk for spreading human papillomavirus via smoke plumes	25 to 50	5 to 50
Podofilox (Condylox)	Simple warts: $200 Extensive warts: $334	Burning at application site (75), pain (50), inflammation (70); low risk for systemic toxicity	45 to 80	5 to 30
Podophyllin resin	Simple warts: $385 Extensive warts: $1,449	Local irritation, erythema, burning, and soreness at application site (75); possibly mutagenicity, oncogenicity	30 to 80	20 to 65
Surgical excision	Simple warts: $210 Extensive warts: $318	Pain (100), bleeding (40), scarring (10); risk for burning and allergic reaction from local anesthetic	35 to 70	20
Trichloroacetic acid	Simple warts: $513 Extensive warts: $966	Local pain and irritation; no systemic side effects	50 to 80	35
Placebo	None	‡	0 to 55	‡