Intervention		Strength of recommendation
Effective
	NSAIDs19	A
Probably effective
	Danazol (Danocrine)*	B
	Extended-cycle oral contraceptives*	B
	Hysterectomy*	B
	Leuprolide acetate (Lupron)*	B
	Depo-medroxyprogesterone acetate (Depo-Provera)*	B
Possibly effective
	Acupuncture/acupressure20,21	B
	COX-2 inhibitors22,23	B
	Fish oil supplements24	B
	Levonorgestrel intrauterine system (Mirena)25	B
	Low-fat vegetarian diet26	B
	Oral contraceptives (intravaginal administration)27	B
	Oral contraceptives (oral administration)†	B
	Thiamine supplementation19	B
	Toki-shakuyaku-san (Japanese herb)19	B
	Topical heat19	B
	Transcutaneous electric nerve stimulation19	B
	Vitamin E supplementation19	B
Uncertain effectiveness
	Behavioral interventions including exercise19	C
	Glyceryl trinitrate	C
	Nifedipine (Procardia)28	C
	Surgical interruption of pelvic nerve pathways29	C
	Terbutaline (Bricanyl)30	C
Ineffective
	Spinal manipulation31,32	B