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Am Fam Physician. 2005;71(6):1068-1071

Increasing numbers of patients in the United States are using herbal therapies and dietary supplements; between 1990 and 1997, there was a fivefold increase in the use of herbal therapies.1 This increase is mirrored in children: more than 50 percent of all young children and more than 30 percent of all adolescents in the United States have used a dietary supplement.2 Family physicians must be prepared to answer difficult questions about the use of herbal dietary supplements in children: Do they work? Are they safe? Which products do you recommend?

The most commonly used supplements are multivitamins, minerals, vitamin C, iron, and ergogenic aids.2 Other dietary supplements commonly used by children are echinacea, peppermint, chamomile, probiotics, ginger, fish oil, and garlic. Adolescents have easy access to dietary supplements that claim to promote weight loss or enhance athletic achievement, school performance, or physical appearance. In a national online survey,3 41 percent of 520 adolescents reported that they had used herbal or green tea, zinc, echinacea or echinacea/goldenseal, ginseng, ginger, ginkgo biloba, soy supplements, omega 3 fatty acids or fish oil, creatine, weight loss supplements, St. John’s wort, valerian, ephedra, or feverfew. Children with chronic conditions such as cystic fibrosis, attention deficit disorder, asthma, atopic dermatitis, allergic rhinitis, cancer, inflammatory bowel disease, and rheumatoid arthritis have higher dietary supplement use than children without these conditions. In children with chronic conditions, the most commonly used dietary supplements were Chinese herbal medicine, ginkgo biloba, echinacea, and St. John’s wort.47

Compared with pharmaceuticals, few studies are available on the clinical effectiveness and safety of herbal and dietary supplements in children, adolescents, infants, and pregnant women. Some risks are unique to children who use dietary supplements: incorrect dosing (based on age and weight of the child), side effects, drug-dietary supplement interactions, and severe allergic reactions. Although the literature is scant, several evidence-based resources can be used at the point of care to help with clinical decision-making (Table 1). Additionally, the American Academy of Family Physicians and the American Academy of Pediatrics have made recommendations on the use of dietary supplements (Table 2).

Altmedex
Subscription service through Micromedex
http://www.micromedex.com/products/healthcare
Holistic Kids
Pediatric integrative medicine education project
http://www.holistickids.org
Longwood Herbal Task Force
Free patient handouts and evidence-based monographs on common childhood herbs
http://www.mcphs.edu/herbal
MedWatch
Report adverse events and drug-herb interactions
http://www.fda.gov/medwatch
Telephone: 800-FDA-1088 (800-221-1088)
National Institutes of Health Office of Dietary Supplements
Free patient handouts available
http://ods.od.nih.gov
Natural Medicines Comprehensive Database
Subscription service with evidence-based monographs
http://www.naturaldatabase.com
Natural Standard
Subscription service with evidence-based monographs
http://www.naturalstandard.com/

Even if a supplement has proven clinical efficacy and safety, the quality of supplements and lack of standardization are obstacles in making recommendations. Mislabeling; misidentification; contamination with heavy metals, pesticides, or herbicides; and adulteration with other herbs or pharmaceuticals could cause toxicity in a child, but not in an adult.8 A recent study9 of Ayurvedic herbal products found that 20 percent were contaminated with heavy metals (e.g., lead, arsenic, mercury); 50 percent of the contaminated products were marketed for children.

Parents give their children dietary supplements for many reasons (e.g., health maintenance, prevention and treatment of acute and chronic diseases), yet parents do not always report the use of these supplements to their family physicians. Of 142 families surveyed while waiting in an emergency department, 45 percent reported giving their child an herbal product.10 Only 45 percent of parents who give their children herbal products reported discussing these products with their child’s primary health care professional.10 Parents learn about supplements from family, popular press, television advertisements, health food stores, and the Internet. It is critical for physicians to know what dietary supplements their patients are using and why, and to clearly document the use of these supplements. The following guidelines8 may be helpful when talking with parents about using dietary supplements:

• Ask all parents which herbal or dietary supplements (e.g., traditional remedies, teas, multivitamins, special foods, over-the-counter products) they are giving their children.

• Encourage parents to seek professional guidance for information on efficacy and safety before using dietary supplements. Dietary supplements may have beneficial effects as well as expected and sometimes unexpected toxicity. Dietary supplements are not regulated as strictly as drugs by the U.S. Food and Drug Administration, so it is truly a case of “buyer beware.” Variable and unpredictable concentrations, ingredients, and contaminants are of concern, especially when such products are used in children.

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