Surgery	Prophylaxis	Comments
Cardiothoracic	Cefazolin or cefuroxime; if beta lactam allergy, vancomycin or clindamycin	72-hour duration advocated by some, but 24 hours is likely to be adequate
Vascular	Cefazolin or cefuroxime; if beta lactam allergy, vancomycin with or without gentamicin, or clindamycin	—
Colon	Oral: neomycin, with erythromycin base or metronidazole	Combination of oral and parenteral prophylaxis may decrease infection rates
	Parenteral: cefoxitin or cefotetan, or cefazolin plus metronidazole
Hip or knee arthroplasty	Cefazolin or cefuroxime; if beta lactam allergy, vancomycin or clindamycin	Infuse antibiotic before tourniquet is inflated
Hysterectomy	Cefazolin, cefotetan, cefoxitin, or cefuroxime	Similar recommendations apply for cesarean delivery