Protocol	Single dose	Multiple dose
Medication	50 mg per square meter of body surface methotrexate IM	Alternate every other day: 1 mg per kg methotrexate IM and 0.1 mg per kg leucovorin*
Laboratory values	LFTs, CBC, and renal function at baseline	LFTs, CBC, and renal function at baseline
	Beta-hCG at baseline, day 4, and day 7	Beta-hCG at baseline, day 1, day 3, day 5, and day 7 until levels decrease
Repeat medication	Repeat regimen if beta-hCG level does not decrease by 15 percent between day 4 and day 7	Repeat regimen (for up to four doses of each medication) if beta-hCG level does not decrease by 15 percent with each measurement
Follow-up	Beta-hCG level weekly, and continue regimen until no longer detected	Beta-hCG level weekly, and continue regimen until no longer detected