brand logo

Am Fam Physician. 2005;72(9):1917

The Committee on Practice Bulletins–Obstetrics of the American College of Obstetricians and Gynecologists (ACOG) has released a practice bulletin on screening for and managing hemoglobinopathies during pregnancy. Practice Bulletin Number 64, “Hemoglobinopathies in Pregnancy,” was published in the July 2005 issue of Obstetrics & Gynecology.

The ACOG recommendations, which are based on good, consistent evidence, include the following:

  • Persons of African, Southeast Asian, and Mediterranean descent are at increased risk of carrying hemoglobinopathies and should be offered screening and genetic counseling. Figure 1 is an algorithm for the antepartum evaluation for hematologic assessment of persons from high-risk groups.

  • Appropriate hemoglobinopathy screening should include a complete blood count and hemoglobin electrophoresis. Solubility tests alone should not be used as screening tools.

  • Parents at high risk of having a child with sickle cell disease or thalassemia should be offered genetic counseling, and a prenatal diagnosis should be obtained through DNA analysis of cultured amniocytes or chorionic villi.

Continue Reading

More in AFP

Copyright © 2005 by the American Academy of Family Physicians.

This content is owned by the AAFP. A person viewing it online may make one printout of the material and may use that printout only for his or her personal, non-commercial reference. This material may not otherwise be downloaded, copied, printed, stored, transmitted or reproduced in any medium, whether now known or later invented, except as authorized in writing by the AAFP.  See for copyright questions and/or permission requests.