Effectiveness

Effective for the treatment of mild to moderate depression

Insufficient evidence to establish effectiveness for the treatment of major depression

Adverse effects

Most common*: transient photosensitivity

Less common: gastrointestinal upset, increased anxiety, minor palpitations, photosensitivity, fatigue, restlessness, dry mouth, increased depression

Dosage

Standardized pills: 900 mg daily (divided into two or three doses)

Cost†

$10 to $25 for a 30-day supply of standardized hypericum

Bottom line

Generally safe, well-tolerated herbal medicine for the treatment of mild to moderate depression