| Simple, uncomplicated skin infections | Five to seven days |
| MSSA | Cephalexin (Keflex), dicloxacillin (Dynapen) | Clindamycin (Cleocin) |
| MRSA | Clindamycin, trimethoprim/sulfamethoxazole (Bactrim, Septra), linezolid (Zyvox) | –– |
| Complex skin and soft-tissue infections | Two to four weeks (varies) |
| MSSA | Nafcillin | Cefazolin (Ancef), clindamycin |
| MRSA | Vancomycin (Vancocin) | Linezolid, daptomycin (Cubicin) |
| Bacteremia | Two to four weeks |
| MSSA | Nafcillin | Cefazolin, vancomycin |
| MRSA | Vancomycin | Linezolid, daptomycin |
| Catheter-related infections | Two weeks, if no infective endocarditis |
| MSSA | Nafcillin | Cefazolin, vancomycin |
| MRSA | Vancomycin | Linezolid, daptomycin |
| Osteomyelitis | Four to six weeks |
| MSSA | Nafcillin, cefazolin | Clindamycin, quinolone plus rifampin (Rifadin) |
| MRSA | Vancomycin | Linezolid, daptomycin |
| Pneumonia | 10 to 14 days |
| MSSA | Nafcillin | Vancomycin, clindamycin |
| MRSA | Vancomycin, linezolid | — |