Type of infection	Antibiotic choice	Alternate antibiotic choices	Length of therapy
Simple, uncomplicated skin infections			Five to seven days
MSSA	Cephalexin (Keflex), dicloxacillin (Dynapen)	Clindamycin (Cleocin)
MRSA	Clindamycin, trimethoprim/sulfamethoxazole (Bactrim, Septra), linezolid (Zyvox)	––
Complex skin and soft-tissue infections			Two to four weeks (varies)
MSSA	Nafcillin	Cefazolin (Ancef), clindamycin
MRSA	Vancomycin (Vancocin)	Linezolid, daptomycin (Cubicin)
Bacteremia			Two to four weeks
MSSA	Nafcillin	Cefazolin, vancomycin
MRSA	Vancomycin	Linezolid, daptomycin
Catheter-related infections			Two weeks, if no infective endocarditis
MSSA	Nafcillin	Cefazolin, vancomycin
MRSA	Vancomycin	Linezolid, daptomycin
Osteomyelitis			Four to six weeks
MSSA	Nafcillin, cefazolin	Clindamycin, quinolone plus rifampin (Rifadin)
MRSA	Vancomycin	Linezolid, daptomycin
Pneumonia			10 to 14 days
MSSA	Nafcillin	Vancomycin, clindamycin
MRSA	Vancomycin, linezolid	—