StudyOutcome
Wood, et al1 n=1076), meta-analysisAcyclovir (Zovirax) 800 mg five times daily for seven days is better than placebo for resolution of pain
Beutner, et al2 (n=760), RCTValacyclovir (Valtrex) 1,000 mg three times daily for seven days is better than acyclovir 800 mg five times daily for seven days for resolution of pain.
Tyring, et al3 (n=419), RCTFamciclovir (Famvir) 500 mg three times daily or 750 mg three times daily for seven days increases rate of lesion healing better than placebo.
Shen, et al4 (n=55), RCTFamciclovir 250 mg three times daily for seven days is equal to acyclovir 800 mg five times daily for seven days for resolution of pain and rate of lesion healing.
Shafran, et al5 (n=559), RCTFamciclovir 750 mg once daily for seven days, 500 mg twice daily for seven days, 250 mg three times daily for seven days, and acyclovir 800 mg five times daily for seven days are all equally effective for resolution of pain and rate of lesion healing.