Type		Cause	Time course	Thyroid function	RAIU at 24 hours	Anti-TPO antibodies	Prevalence or incidence
Painful
Subacute granulomatous		Infection (viral)	Subacute	Hyper, hypo, or both, then normal	< 5 percent	Low or absent titer	Four to five cases per 100,000 persons
Suppurative		Infection (nonviral)	Acute (nonbacterial may be subacute)	Normal	Normal	Absent	Undetermined but very rare
Radiation or trauma		Destruction of thyroid parenchyma	Acute	Hyper, hypo, or normal	< 5 percent	Absent*	1 percent of those receiving131I for Graves' disease
Painless
Hashimoto's disease		Autoimmune	Chronic	Normal or hypo	Normal or low	High titer, persistent	5 to 10 percent
Postpartum		Autoimmune	Subacute	Hyper, hypo, or both, then normal	< 5 percent	High titer, persistent	5 to 7 percent of postpartum women
Subacute lymphocytic		Autoimmune	Subacute	Hyper, hypo, or both, then normal	< 5 percent	Present, persistent	10 to 15 cases per 100,000 persons
Drug-induced
	Amiodarone (Cordarone)	Inflammation	Acute or subacute	Hyper or hypo	Low	Absent	10 percent
	Interferon-alfa (Infergen; Intron A, Roferon-A, Rebetron combination therapy)	Inflammation	Acute or subacute	Hyper or hypo	Low	5 to 10 percent positive	10 to 15 percent
	Interleukin-2	Inflammation	Acute or subacute	Hyper or hypo	Low	< 10 percent positive	Undetermined
	Lithium	Autoimmune	Acute or subacute	Hyper then normal, or low	Low	33 percent positive	13 cases per 100,000 persons
Riedel's		Fibrosis	Chronic	Normal or low	Normal or low	Present	Undetermined