Maternal HBsAg status	Single-antigen vaccine		Combination vaccine
	Dose	Age	Dose	Age
Positive	1*	Birth (within 12 hours)	1*	Birth (within 12 hours)
	HBIG†	Birth (within 12 hours)	HBIG	Birth (within 12 hours)
	2	One to two months	2	Two months
	3‡	Six months	3	Four months
			4‡	Six months (DTaP/HepB/IPV vaccine [Pediarix]) or 12 to 15 months (Hib-HepB vaccine [Comvax])
Unknown§	1*	Birth (within 12 hours)	1*	Birth (within 12 hours)
	2	One to two months	2	Two months
	3‡	Six months	3	Four months
			4‡	Six months (Pediarix) or 12 to 15 months (Comvax)
Negative	1*||	Birth (before discharge)	1*||	Birth (before discharge)
	2	One to two months	2	Two months
	3‡	Six to 18 months	3	Four months
			4‡	Six months (Pediarix) or 12 to 15 months (Comvax)