Evidence of antecedent group A streptococcal infection

Throat culture positive for group A streptococcal infection

Positive result for rapid streptococcal antigen test

High or rising titer of antistreptococcal antibodies

Major manifestations

Carditis

Polyarthritis

Chorea

Erythema marginatum

Subcutaneous nodules

Minor manifestations

Arthralgia

Fever

Elevated erythrocyte sedimentation rate or C-reactive protein level

Prolonged PR interval