Drug	Dosage range (mg per day)	Half-life (hours)	Active metabolite?
Selective serotonin reuptake inhibitor
Citalopram (Celexa)	10 to 60	35	No
Escitalopram (Lexapro)	10 to 30	27 to 32	No
Fluoxetine (Prozac)	20 to 80	84 to 144	Yes
Paroxetine (Paxil)	10 to 60	21	No
Paroxetine CR (Paxil CR)	12.5 to 62.5	15 to 20	No
Sertraline (Zoloft)	50 to 200	26	Yes
Atypical antidepressant
Bupropion (Wellbutrin)	75 to 450	12 to 30	Yes
Buproprion SR (Wellbutrin SR)	100 to 400	12 to 30	Yes
Buproprion XL (Wellbutrin XL)	150 to 450	12 to 30	Yes
Duloxetine (Cymbalta)*	40 to 60	11 to 16	Yes
Mirtazapine (Remeron)	15 to 45	20 to 40	No
Trazodone (Desyrel)	50 to 400	7.1	Yes
Venlafaxine (Effexor)	75 to 450	3 to 13	Yes
Venlafaxine XR (Effexor XR)	75 to 450	3 to 13	Yes
Monoamine oxidase inhibitors
Phenelzine (Nardil)	15 to 90	1.2	Yes
Tricyclic antidepressant*
Amitriptyline	25 to 300	9 to 25	Yes
Clomipramine (Anafranil)	25 to 250	22 to 84	No
Desipramine (Norpramin)	25 to 300	14.3 to 24.7	No
Doxepin (Sinequan)	25 to 300	11 to 23	No
Imipramine (Tofranil)	25 to 300	10 to 16	Yes
Nortriptyline (Pamelor)	25 to 150	18.2 to 35	No