Clinical recommendation	Evidence rating	References
Intravenous bisphosphonates are recommended for treating hypercalcemia of malignancy to improve quality of life and to reduce skeletal complications, bone pain, and the need for analgesic medications.	B	14,19,20
Outpatient treatment should be considered for patients with febrile neutropenia who are older than 16 years and who have a low risk of infection.	B	27
Routine use of antivirals, granulocyte transfusions, and colony-stimulating factors is not recommended for patients with febrile neutropenia.	C	23
Patients with epidural spinal cord compression should receive prompt treatment to improve outcomes.	C	2,31
Patients with cancer who have new-onset back pain should be evaluated for epidural spinal cord compression.	C	32