Condition	Rash presentation	Pregnancy risk	Treatment
Pruritic urticarial papules and plaques of pregnancy17	Intensely pruritic urticarial plaques and papules with or without erythematous patches of papules and vesicles; rash first appears on abdomen, often along striae and occasionally involves extremities; face usually is not affected	No identified adverse effects	Oral antihistamines and topical corticosteroids for pruritus; systemic corticosteroids for extreme symptoms
Prurigo of pregnancy1	Erythematous papules and nodules on the extensor surfaces of the extremities	No identified adverse effects	Midpotency topical corticosteroids and oral antihistamines
Intrahepatic cholestasis of pregnancy1,18,19	Excoriations from scratching; distribution is nonspecific	Risk of premature delivery, meconium-stained amniotic fluid, intrauterine fetal demise	Oral antihistamines for mild pruritus; ursodeoxycholic acid (ursodiol [Actigall]) for more severe cases
Pemphigoid gestationis20,21	Pruritic papules, plaques, and vesicles evolving into generalized vesicles or bullae; initial periumbilical lesions may generalize, although the face, scalp, and mucous membranes usually are not affected	Newborns may have urticarial, vesicular, or bullous lesions; risk of premature deliveries andnewborns who are small for gestational age	Oral antihistamines and topical corticosteroids for mild cases; systemic oral corticosteroids for severe cases
Impetigo herpetiformis22,23	Round, arched, or polycyclic patches covered with small painful pustules in a herpetiform pattern; most commonly appears on thighs and groin, but rash may coalesce and spread to trunk and extremities; face, hands, and feet are not affected; mucous membranes may be involved	Reports of increased fetal morbidity	Systemic corticosteroids; antibiotics for secondarily infected lesions
Pruritic folliculitis of pregnancy1	Erythematous follicular papules and sterile pustules on the abdomen, arms, chest, and back	No identified adverse effects	Topical corticosteroids, topical benzoyl peroxide (Benzac), or ultraviolet B light therapy