Author (year)ProcedureNumber of patientsDrug/dosageMyocardial ischemiaMyocardial infarctionDeath
ControlDrugControlDrugControlDrug
Alpha agonists
Wallace (2004)38 Noncardiac190Clonidine (Catapres), 0.2 mg oral and patch20/65 (31%)18/125* (14%)NANANANA
Stuhmeier (1996)34 Vascular297Clonidine, 2 mcg per kg orally59/152 (39%)35/145 (24%)4/152 (3%)0/145 (0)2/152 (1%)1/145 (0.7%)
Ellis (1994)39 Noncardiac61Clonidine for 72 hours after surgery, then 0.3 mg orally 60 to 90 minutes before surgery5/26 (19%)6/28 (21%)NANANANA
McSPI (1997)40 Noncardiac300Mivazerol (not available in the United States), 1.5 mcg per kg per hourIntraoperative 34/99 (34%)37/180 (20%)6/103 (6%)3/197 (2%)NANA
Statins
Durazzo (2004)32 Vascular100Atorvastatin (Lipitor), 20 mg1/50 (2%)0/50 (0)8/50 (16%)3/50 (6%)2/50 (4%)1/50 (2%)