Anticoagulant	Prophylactic dosage	Therapeutic dosage	FDA-approved prophylactic conditions	FDA-approved therapeutic conditions	Cost*†
Warfarin (Coumadin)	Usual maintenance: 2 to 10 mg daily	Usual maintenance: 2 to 10 mg daily	See Table 2	See Table 2	$1
Unfractionated heparin	5,000 U every eight to 12 hours	For DVT, start with 80 U per kg bolus, then 18 U per kg per hour infusion	Prophylaxis for patients at risk of developing DVT and PE Prophylaxis of peripheral artery embolization	Treatment of DVT and PE Atrial fibrillation with embolism Prevention of clotting during arterial and cardiac surgery Treatment of peripheral artery embolization Treatment of consumptive coagulopathies	9
Low-molecular-weight heparin Dalteparin (Fragmin)	5,000 IU daily	100 IU per kg every 12 hoursor 200 IU per kg every 24 hours	Unstable angina and non–Q wave MI with ASA Conditions that predispose to DVT: joint replacement surgery, abdominal surgery, immobilized medical patients	None	117
Enoxaparin (Lovenox)	40 mg daily	1 mg per kg every 12 hoursor 1.5 mg per kg every 24 hours	Unstable angina and non–Q wave MI with ASA Conditions that predispose to DVT: joint replacement surgery, abdominal surgery, immobilized medical patients	Inpatient treatment of DVT with and without PE with warfarin Outpatient DVT without PE with warfarin	111
Nadroparin (not available in United States)	38 IU per kg daily	87 IU per kg every 12 hours	None	None	—
Tinzaparin (Innohep)	3,500 IU daily	175 IU per kg per 24 hours	None	Treatment of DVT and PE with warfarin	71
Bivalirudin (Angiomax)	—	1 mg per kg IV bolus	None	During PTCA for unstable angina	2,204 for one four-hour treatment
		2.5 mg per kg per hour for four hours; with ASA 325 mg
		May continue with 0.2 mg per kg for up to 20 hours
Desirudin (Ipravask)	15 mg every 12 hours	—	DVT prophylaxis after hip replacement	None	‡
Lepirudin (Refludan)	—	0.4 mg per kg bolus (maximum: 45 mg)or 0.15 mg per kg per hour (maximum: 16.5 mg) for two to 10 days	Prophylaxis of venous thromboembolism in patients with HIT	Treatment of thrombosis in patients with HIT	1,248
Argatroban (Acova)	—	2 mcg per kg per minute	Prophylaxis of venous thromboembolism in patients with HIT	Treatment of thrombosis in patients with HIT	1,260
Ximelagatran (not available in United States)	24 to 36 mg twice daily	20 to 60 mg twice daily	None	None	—
Fondaparinux (Arixtra)	2.5 mg daily	5 mg for a patient less than 50 kg	DVT prophylaxis after hip or knee replacement or abdominal surgery	Bridge DVT or PE to warfarin	108
		7.5 mg for 50 to 100 kg
		10 mg for more than 100 kg