Therapy	Triglyceride reduction (%)	LDL-C increase/reduction (%)	HDL-C increase (%)	Possible side effects
Statins	20 to 40	18 to 55 reduction	5 to 15	Myopathy, rhabdomyolysis, elevated liver enzyme levels
Atorvastatin (Lipitor), 10 to 80 mg daily
Fluvastatin (Lescol), 20 to 80 mg daily at bedtime
Lovastatin (Mevacor), 10 to 80 mg daily at bedtime
Pravastatin (Pravachol), 10 to 80 mg daily
Rosuvastatin (Crestor), 5 to 20 mg daily
Simvastatin (Zocor), 5 to 80 mg dailyat bedtime
Fibrates	40 to 60	5 to 30 increase	15 to 25	Rhabdomyolysis, especially with a gemfibrozil/statin combination
Fenofibrate (Tricor), 48 to 145 mg daily
Gemfibrozil (Lopid), 600 mg twice daily
Niacin	30 to 50	5 to 25 reduction	20 to 30	Flushing; worsening glycemic control; elevated liver enzyme levels, especially with OTC sustained-release niacin
OTC immediate-release niacin, 0.5 to 2 g two or three times daily
OTC sustained-release niacin, 250 to 750 mg once or twice daily
Prescription niacin, 500 mg to 2 g daily at bedtime
Fish oil, 2 to 4 g total EPA/DHA daily	30 to 50	5 to 10 increase	5 to 10	Fishy aftertaste, gastrointestinal upset
OTC omega-3 fatty acid capsules
Prescription omega-3-acid ethyl esters (Omacor), 1 to 2 g twice daily