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A more recent article on acute pancreatitis is available.

Am Fam Physician. 2007;75(10):1513-1520

Author disclosure: Nothing to disclose.

Mild acute pancreatitis has a low mortality rate, but patients with severe acute pancreatitis are more likely to develop complications and have a much higher death rate. Although serum amylase and lipase levels remain the most widely used diagnostic assays for acute pancreatitis, other biomarkers and inflammatory mediators such as trypsinogens are being investigated for clinical use. Ranson's criteria, the Imrie scoring system, the Acute Physiology and Chronic Health Evaluation (APACHE II) scale, and the Computed Tomography Severity Index are systems for classifying severity of this disease; the Atlanta classification is widely used to compare these systems and standardize clinical trials. New developments in imaging modalities such as endoscopic ultrasonography and magnetic resonance cholangiopancreatography increase the options available to physicians for determining the cause of pancreatitis and assessing for complications. Enteral nutrition is preferred to parental nutrition for improving patient outcomes. Clinical trials are ongoing to evaluate the role, selection, and timing of antibiotics in patients with infected necrosis.

Acute pancreatitis is a reversible inflammatory process of the pancreas. Although the disease process may be limited to pancreatic tissue, it also can involve peripancreatic tissues or more distant organ sites. Acute pancreatitis may occur as an isolated attack or may be recurrent. It has a variety of causes and can range in severity from mild to severe and life threatening. Some patients may require brief hospitalization, whereas others may be critically ill with multiple organ dysfunction requiring intensive care monitoring. Mild acute pancreatitis has a very low mortality rate (less than 1 percent),1,2 whereas the death rate for severe acute pancreatitis can be 10 to 30 percent depending on the presence of sterile versus infected necrosis.3 In the United States, up to 210,000 patients per year are admitted to a hospital for acute pancreatitis. 1,4

Clinical recommendationEvidence ratingReferences
Total enteral nutrition is equal to or more effective than total parenteral nutrition for nutritional management of patients with severe pancreatitis.A36
Evaluate for less-common causes of pancreatitis (e.g., sphincter of Oddi dysfunction, pancreas divisum, pancreatic duct strictures) with endoscopic retrograde cholangiopancreatography.C29
Contrast-enhanced computed tomography is the standard imaging technique for detection of acute pancreatitis. Computed tomography is not generally indicated for patients with mild, uncomplicated pancreatitis, but should be reserved for cases of clinical or biologic worsening.C13
It is controversial whether antibiotics reduce mortality in patients with necrotic pancreatitis.B37,38
Urgent endoscopic retrograde cholangiopancreatography is indicated in patients with or at risk of biliary sepsis, biliary obstruction, cholangitis, or worsening or persistent jaundice.A30

Risk Factors

The most common risk factors for acute pancreatis are gallbladder disease (often caused by choledocholithiasis) and chronic alcohol consumption. Table 1 lists risk factors for acute pancreatitis.5 Given newly emerging diagnostic modalities, recent guidelines have recommended against the diagnosis of “idiopathic acute pancreatitis.”6

Anatomic or functional disorders (e.g., pancreas divisum, sphincter of Oddi dysfunction)
Autoimmune (e.g., systemic lupus erythematosus)
Choledocholithiasis
Chronic alcohol consumption
Congenital anomalies
Drug-induced hypertriglyceridemia (triglycerides greater than 1,000 mg per dL [11.30 mmol per L])
Gallstones
Hypercalcemia, hyperparathyroidism
Hypothermia
Idiopathic
Infections (e.g., viral, bacterial, parasitic, fungal)
Pancreatic or ampullary tumors
Traumatic or postprocedure (e.g., endoscopic retrograde cholangiopancreatography or after abdominal surgery)
Vascular (e.g., vasculitis)

Clinical Presentation

The hallmark symptom of acute pancreatitis is the acute onset of persistent upper abdominal pain, usually with nausea and vomiting. The usual locations of the pain are the epigastric and periumbilical regions. The pain may radiate to the back, chest, flanks, and lower abdomen. Patients are usually restless and bend forward (the knee-chest position) in an effort to relieve the pain because the supine position may exacerbate the intensity of symptoms.7 Physical examination findings are variable but may include fever, hypotension, severe abdominal tenderness, guarding, respiratory distress, and abdominal distention.2,8

Diagnosis

No single laboratory or clinical sign is pathognomonic for acute pancreatitis; many bio-markers and inflammatory mediators for predicting the severity of acute pancreatitis are being evaluated. The initial laboratory evaluation should include amylase and lipase levels; complete blood count with differential; metabolic panel (blood urea nitrogen, creatinine, glucose, and calcium levels); triglyceride level; urinalysis; and arterial blood gases.9

Amylase and lipase, secreted by the acinar cells of the pancreas, are the most common laboratory markers used to establish the diagnosis of acute pancreatitis5,10 (Table 25,11 ). Elevated amylase and lipase levels can be non-specific, depending on the time since onset of pain, other intra-abdominal processes, and concomitant chronic diseases such as renal insufficiency.11,12 Amylase levels may be normal in patients with alcoholism who present with acute pancreatitis, especially if they have had previous attacks of alcoholic pancreatitis; thus, serial testing may not be helpful. Plasma lipase is more sensitive and specific than plasma amylase.11,13

Recent research has examined potential biologic markers for predicting the severity and prognosis of pancreatitis (Table 25, 11 ). Trypsinogens and pancreatic proteases involved in the autodigestive processes of acute pancreatitis appear promising. Other investigational serologic markers include trypsinogen activation peptide, C-reactive protein, procalcitonin, phospholipase A2, and the cytokines interleukin-6 and inter-leukin-8.11,12,14,15 Currently, these markers have limited clinical availability, but there is significant interest in better understanding markers of immune response and pancreatic injury because these could be valuable tools for reliably predicting the severity of acute pancreatitis and supplementing imaging modalities.

Laboratory testTime of onset (hours)PurposeClinical observation/limitations
Alanine transaminase12 to 24Diagnosis and etiologyAssociated with gallstone pancreatitis; threefold elevation or greater in the presence of acute pancreatitis has a positive predictive value of 95 percent in diagnosing acute gallstone pancreatitis
Amylase2 to 12DiagnosisMost accurate when at least twice the upper limit of normal; amylase levels and sensitivity decrease with time from onset of symptoms
C-reactive protein24 to 48Predictive of severityLate marker; high levels associated with pancreatic necrosis
Interleukin-618 to 48Predictive of severityEarly indication of severity
Interleukin-812 to 24Predictive of severityEarly indication of severity
Lipase4 to 8DiagnosisIncreased sensitivity in alcohol-induced pancreatitis; more specific and sensitive than amylase for detecting acute pancreatitis
Phospholipase A224Predictive of severityAssociated with development of pancreatic necrosis and pulmonary failure
Procalcitonin24 to 36Predictive of severityEarly detection of severity; high concentrations in infected necrosis
Trypsinogen activation peptideWithin a few hoursDiagnosis and predictive of severityEarly marker for acute pancreatitis and close correlation to severity

Prognosis

Early evaluation and risk stratification for patients with acute pancreatitis are important to differentiate patients with mild versus severe disease because patients with severe disease often need intensive care treatment. Several scoring systems can predict the severity of pancreatitis, and recent work has attempted to compare their relative predictive values.

Ranson's criteria,16 the Imrie scoring system,17 the Acute Physiology and Chronic Health Evaluation (APACHE II) scale,18 and the Computed Tomography (CT) Severity Index19 have been developed and validated to predict adverse outcomes, including mortality, in patients with pancreatis (Table 31619).

APACHE II scale
Equation includes the following factors: age, rectal temperature, mean arterial pressure, heart rate, PaO2, arterial pH, serum potassium, serum sodium, serum creatinine, hematocrit, white blood cell count, Glasgow Coma Scale score, chronic health status
Scoring: Can be calculated athttp://www.sfar.org/scores2/apache22.html#calcul
CT Severity Index
CT grade
A is normal pancreas (0 points)
B is edematous pancreas (1 point)
C is B plus mild extrapancreatic changes (2 points)
D is severe extrapancreatic changes plus one fluid collection (3 points)
E is multiple or extensive fluid collections (4 points)
Necrosis score:
None (0 points)
> One third (2 points)
< One third but less than one half (4 points)
> One half (6 points)
Scoring: CT grade + necrosis score
Imrie scoring system
Age > 55 years
White blood cell count > 15,000 per mm3 (15.0 × 109 per L)
Blood glucose > 180 mg per dL (10 mmol per L) in patients without diabetes
Serum lactate dehydrogenase > 600 U per L
Serum AST or ALT > 100 U per L
Serum calcium < 8 mg per dL
PaO2 < 60 mm Hg
Serum albumin < 3.2 g per dL (32 g per L)
Serum urea > 45 mg per dL (16.0 mmol per L)
Scoring: One point for each criterion met 48 hours after admission
Ranson's criteria
At admission or diagnosis:
Age > 55 years
White blood cell count > 16,000 per mm3 (16.0 × 109 per L)
Blood glucose > 200 mg per dL (11.1 mmol per L)
Serum lactate dehydrogenase > 350 U per L
AST > 250 U per L
During initial 48 hours:
Hematocrit decrease > 10 percent
Blood urea nitrogen increase > 5 mg per dL (1.8 mmol per L)
Serum calcium < 8 mg per dL (2 mmol per L)
Base deficit > 4 mmol per L (4 mEq per L)
Fluid sequestration > 6,000 mL
PaO2 < 60 mm Hg
Scoring: One point for each criterion met

Research has shown some advantages of the CT Severity Index in predicting the severity of acute pancreatitis compared with the other systems. One study found that a CT Severity Index score of 5 or greater correlated with prolonged hospitalization and higher rates of mortality and morbidity.20 A CT Severity Index score of 5 or greater was associated with a mortality rate 15 times higher than in those with a score of less than 5. No association was found between Ranson's criteria and APACHE II scale scores and mortality or length of hospitalization.20

Another study demonstrated that the CT Severity Index was a stronger predictor of severe acute pancreatitis than Ranson's criteria or the APACHE II scale; however, the CT Severity Index was conducted 72 hours after admission, whereas the APACHE II scale and Ranson's criteria scores were calculated at 24 and 48 hours, respectively.21

An observational study showed that CT Severity Index scores, when obtained within 48 hours, correlated better with complications and mortality than Ranson's criteria.22 Because of the number of available scoring systems, the Atlanta Classification of Severe Acute Pancreatitis has become widely used as a means of comparing scores (Ranson's criteria, APACHE II scale, and contrast–enhanced CT) to define severe acute pancreatitis,23 which has helped standardize clinical research trials.

Table 4 summarizes evidence comparing these prognostic systems and patient-related outcomes such as ruling out severe acute pancreatitis.8,21,24 The higher the prognostic score, the poorer the clinical outcome, including mortality. Irrespective of scoring criteria, signs of organ failure within 24 hours of admission significantly increase the risk of death; and thus, physiologic response to treatment needs to be monitored closely.25

Prognostic scoring systemAssociated outcomesPositive LRNegative LR
APACHE II score ≥ 8 at 24 hoursNeed for intensive care unit, severity, secondary pancreatic infection, pancreatic necrosis, mortality, organ failure, and longer hospital stay1.7 to 4.00.25
Imrie score ≥ 3Mortality, severity, pancreatic fluid collections4.60.36
Ranson's criteria score > 3 at 48 hoursMajor complications, severity, organ failure, pancreatic necrosis, mortality, longer hospital stay2.4 to 2.50.47

Advances in Radiologic Imaging Techniques

Radiologic imaging is used to confirm or exclude the clinical diagnosis, establish the cause, assess severity, detect complications, and provide guidance for therapy. In recent years, the range of imaging modalities has greatly expanded. Traditional imaging modalities include plain film radiography, abdominal ultrasonography, CT scans, and endoscopic retrograde cholangiopancreatography (ERCP); newer options include endoscopic ultrasonography and magnetic resonance cholangiopancreatography (MRCP). Recent research in this area has focused on development of these tests and the better understanding of their application to clinical care.

Transabdominal ultrasonography is used to determine cholelithiasis.9 Bowel gas can limit the accuracy of pancreatic imaging, but if the pancreas is visualized, then imaging can reveal pancreatic enlargement, echotextural changes, and peripancreatic fluid.26 Contrast-enhanced CT is the standard imaging technique for detection of acute pancreatitis.27 CT generally is not indicated for patients with mild, uncomplicated pancreatitis but should be reserved for cases of clinical or biologic worsening.13 It is controversial whether routine use of CT increases length of hospital stay,28 and the potential risk of contrast media-induced morbidity limits its use in certain patients. Magnetic resonance imaging is not commonly used but may be indicated if better visualization of peripancreatic inflammation, necrosis, or fluid collections is needed.13

ERCP is helpful in evaluating less-common causes of pancreatitis (e.g., microlithiasis; sphincter of Oddi dysfunction; pancreas divisum; and pancreatic duct strictures, which can be benign or malignant).29 Urgent ERCP is indicated in patients at risk of or with evidence of biliary sepsis, severe pancreatitis with biliary obstruction, cholangitis, elevated bilirubin, worsening and persistent jaundice, or signs of worsening pain in the setting of an abnormal ultrasound examination because these patients may need more immediate surgical or gastroenterologic intervention.30,31 In patients with severe gallstone pancreatitis, morbidity and mortality is reduced with the use of early selective ERCP.32

MRCP is a newer, noninvasive technique that has been referred to as “the pancreato-gram.”33 MRCP can be used preoperatively to determine which patients would benefit from ERCP.27 MRCP has been found to be as accurate as contrast-enhanced CT in predicting the severity of pancreatitis and identifying pancreatic necrosis.32 Unlike ERCP, MRCP does not have interventional capability for stone extraction, stent insertion, or biopsy. MRCP is less sensitive for detection of small stones (i.e., smaller than 4 mm), small ampullary lesions, and ductal strictures.33 MRCP can assess pancreatic and peripancreatic cysts.34 It is helpful in patients when ERCP is not possible or is unsuccessful.32

Another new technology is endoscopic ultrasonography, which is highly accurate in documenting stones and tumors but is used less often than ERCP. Endoscopic ultrasonography is useful in obese patients and patients with ileus, and can help determine which patients with acute pancreatitis would benefit most from therapeutic ERCP.31 Endoscopic ultrasonography can assist with endoscopic transmural cyst and abscess drainage. Endoscopic ultrasonography and MRCP show promise in increasing the range of options available to search for the cause of acute pancreatitis. Table 5 compares the sensitivity and specificity of various imaging techniques.8,13,26,32

Imaging techniqueEffectiveness
Contrast-enhanced computed tomography78 percent sensitivity and 86 percent specificity for severe acute pancreatitis
Endoscopic ultrasonography100 percent sensitivity and 91 percent specificity for gallstones
Magnetic resonance cholangiopancreatography81 to 100 percent sensitivity for detecting common bile duct stones
98 percent negative predictive value and 94 percent positive predictive value for bile duct stones
As accurate as contrast-enhanced computed tomography in predicting severity of pancreatitis and identifying pancreatic necrosis
Magnetic resonance imaging83 percent sensitivity and 91 percent specificity for severe acute pancreatitis
Transabdominal ultrasonography87 to 98 percent sensitivity for the detection of gallstones

Treatment Issues for Acute Pancreatitis

Aggressive volume repletion, pain control, close monitoring of hemodynamic and volume statuses, attention to nutritional needs, and monitoring for complications are essential in patients with acute pancreatitis. Because several clinical guidelines and reviews describe these management issues in detail,6,9,35 this article only provides a brief update based on recent developments in two important aspects of management: nutrition and the role of antibiotics.

Physicians often find the decision about nutritional management in patients with acute pancreatitis challenging because historically it was believed that pancreatic rest was needed. However, total enteral nutrition, when compared with total parenteral nutrition, has been shown to have clear benefits in patients with severe acute pancreatitis. A meta-analysis concluded that total enteral nutrition is equal to if not better than total parenteral nutrition.36 However, more research is needed to clarify which type of total enteral nutrition (i.e., oral, nasogastric, or nasojejunal feeding) most benefits patient outcomes. Several randomized studies have shown that nasojejunal feeding prevents morbidity and mortality, possibly by preventing development of infected necrosis by inhibiting bacterial translocation from the gut.15 It is often the preferred option in patients with severe pancreatitis but may not be possible if ileus is present.

One of the late complications of severe acute pancreatitis is pancreatic necrosis. Mortality increases when necrosis becomes infected. Antibiotics have been shown to improve patient outcomes in severe acute pancreatitis. A recent, double-blind, randomized controlled trial of 114 patients with acute necrotic pancreatitis receiving ciprofloxacin (Cipro), metronidazole (Flagyl), or placebo found no significant difference in the rate of infected pancreatic necrosis, systemic complications, or mortality.37 Yet, meta-analyses of studies of acute necrotic pancreatitis conclude that prophylactic antibiotics can decrease pancreatic sepsis, mortality, extra-pancreatic infections, and surgical rates.38 Because evidence is mixed on the issue of prophylactic antibiotics for necrotic pancreatitis, the aforementioned benefits must be weighed carefully with risks (e.g., adverse effects, fungal infections, drug resistance).

Surgical debridement also may be indicated for infected necrosis. Surgery for sterile necrosis is indicated only if the patient clinically deteriorates or if there is no improvement. Surgery is usually performed no earlier than two weeks after the onset of symptoms. When compared with immediate surgery, this delay has been shown to decrease the mortality rate.9,39 Surgical techniques are evolving, and ongoing research is evaluating the effectiveness of various approaches.

Figure 1 is an overview and summary of the key principles and steps involved in the diagnostic evaluation, differential diagnosis, prognostic evaluations, and treatment of mild and severe acute pancreatitis.4,79,11,15,35

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