brand logo

Am Fam Physician. 2007;75(12):1886

Guideline source: American Academy of Pediatrics

Literature search described? No

Evidence rating system used? No

Published source: Pediatrics, November 2006

Chronic uveitis occurs in 2 to 34 percent of children with juvenile rheumatoid arthritis. Uveitis can lead to cataracts, glaucoma, band keratopathy, phthisis bulbi, and blindness. Diagnosis of early uveitis is not possible by direct ophthalmoscopy, so a slit-lamp examination must be performed to check for inflammatory cells and increased protein within the anterior chamber of the eye.

There are three major onset types of juvenile rheumatoid arthritis: oligoarticular, polyarticular, and systemic. Children with oligoarticular-onset juvenile rheumatoid arthritis are at the highest risk of developing chronic uveitis and are usually diagnosed between one and five years of age. Chronic uveitis can sometimes be detected at the time of the arthritis diagnosis; if it cannot be detected at diagnosis, it usually will present within the next four to seven years.

The presence of antinuclear antibodies is the serologic marker most strongly associated with chronic uveitis. The antibodies are usually detected in low to moderate titers on HEp-2 cells. Their antigenic specificity is unknown. Immunogenic factors may pre-dispose some children to the development of chronic uveitis; the associated alleles can most often be found in the major histocompatability complex region of chromosome 6 and involve specificities in the HLS-DR, DP, and DQ regions.

The onset of chronic uveitis is usually asymptomatic, which underlines the importance of the slit-lamp examination by an ophthalmologist at the time of diagnosis with arthritis and periodically thereafter. Possible symptoms, though very rare, include redness of the eye, decreased vision, unequal pupils, ocular pain, and headache. Any of these symptoms should prompt an immediate eye examination.

All patients should have a slit-lamp examination within one month of diagnosis with juvenile rheumatoid arthritis. The recommended frequency of ophthalmologic visits for children without confirmed uveitis is given in Table 1. Children with diagnosed uveitis will have their examination schedule determined by a pediatric ophthalmologist.

The rightsholder did not grant rights to reproduce this item in electronic media. For the missing item, see the original print version of this publication.

Continue Reading

More in AFP

Copyright © 2007 by the American Academy of Family Physicians.

This content is owned by the AAFP. A person viewing it online may make one printout of the material and may use that printout only for his or her personal, non-commercial reference. This material may not otherwise be downloaded, copied, printed, stored, transmitted or reproduced in any medium, whether now known or later invented, except as authorized in writing by the AAFP.  See permissions for copyright questions and/or permission requests.