Clinical Recommendation	Evidence Rating	References
Most causes of acute nausea and vomiting can be determined from the history and physical examination.	C	2
Initial evaluation should focus on signs or symptoms that indicate urgent treatment, surgical intervention, or hospitalization.	C	2
Diagnostic testing for nausea and vomiting should be targeted at finding the etiology suggested by a thorough history and physical examination.	C	15, 17–19
Fluid imbalances, electrolyte abnormalities, and nutritional deficiencies should be corrected.	C	2
Treatment should be directed at the underlying etiology of the nausea and vomiting. If no etiology is found, the patient should be treated symptomatically with antiemetic and prokinetic therapy, and other etiologies of chronic unexplained nausea and vomiting (e.g., psychogenic, bulimic, rumination, functional) should be considered.	B	20–23