| Treat fibromyalgia with a multidimensional clinical approach comprising patient education, cognitive behavior therapy, pharmacotherapy, and exercise. | A | 22 | Based on five RCTs |
| Use antidepressant medications to improve pain, sleep quality, and global well-being in patients with fibromyalgia. | B | 23 | Based on few RCTs |
| Prescribe cyclobenzaprine (Flexeril) 10 to 30 mg at bedtime to improve sleep and decrease pain in patients with fibromyalgia. | A | 31 | Systematic review of RCTs |
| Advise patients that aerobic exercise training has beneficial effects on fibromyalgia symptoms. | A | 35, 36 | Systematic review of RCT |