Clinical recommendation	Evidence rating	References
Exercise, cognitive behavior therapy, and relaxation therapy are recommended as effective, nonpharmacologic treatments for chronic insomnia.	A	4, 7, 12, 16
Melatonin is effective in patients with circadian rhythm sleep disorders and is safe when used in the short term.	B	20
Benzodiazepines are effective for treating chronic insomnia but have significant adverse effects and the risk of dependency.	B	4, 22, 36
Nonbenzodiazepines (e.g., eszopiclone [Lunesta], zaleplon [Sonata], zolpidem [Ambien]) are effective treatments for chronic insomnia and, based on indirect comparisons, appear to have fewer adverse effects than benzodiazepines.	B	4