Trials*Treatment regimenNo. of participantsComplete response (%)Partial response(%)
Diclofenac 3% (Solaraze) in hyaluronan 2.5% gel
Wolf, et al., 200138 Twice daily for 90 days120Treatment: 47.0
Vehicle: 19.0
Imiquimod 5% cream (Aldara)
Korman, et al., 200535 Once daily, three times per week, for 16 weeks492Treatment: 48.3Treatment: 64.0
Vehicle: 7.2Vehicle: 13.6
Lebwohl, et al., 200433 Once daily, two times per week, for 16 weeks436Treatment: 45.1Treatment: 59.1
Vehicle: 3.2Vehicle: 11.8
(95% CI, 34.9 to 49)(95% CI, 39.5 to 55.1)
Szeimies, et al., 200434 Once daily, three times per week, for 16 weeks286Treatment: 57.1Treatment: 72.1
Vehicle: 2.2Vehicle: 4.3