Treatment	Comment	Options
Eradication of Helicobacter pylori	Treatment duration is 10 to 14 days (although courses lasting one to seven days have been reported to have comparable effectiveness^21,22)	Omeprazole (Prilosec) 20 mg two times daily or lansoprazole (Prevacid) 30 mg two times daily plus amoxicillin 1 g two times daily or metronidazole (Flagyl) 500 mg two times daily (if allergic to penicillin) plus clarithromycin (Biaxin) 500 mg two times daily Ranitidine bismuth citrate (Tritec)* 400 mg two times daily plus clarithromycin 500 mg two times daily or metronidazole 500 mg two times daily plus tetracycline 500 mg two times daily or amoxicillin 1 g two times daily Levofloxacin (Levaquin) 500 mg daily Levofloxacin (Levaquin) 500 mg daily plus amoxicillin 1 g two times daily plus pantoprazole (Protonix) 40 mg two times daily Bismuth subsalicylate (Pepto-Bismol) 525 mg (two tablets) four times daily plus metronidazole 250 mg four times daily plus tetracycline 500 mg four times daily plus H₂ blocker for 28 days or proton pump inhibitor for 14 days
Eradication of Helicobacter pylori	Eradication rates 80 to 90 percent or higher
Histamine H₂ blockers	70 to 80 percent healing in duodenal ulcer after four weeks, 87 to 94 percent after eight weeks	Ranitidine (Zantac) 150 mg two times daily or 300 mg at night
		Famotidine (Pepcid) 20 mg two times daily or 40 mg at night
		Cimetidine (Tagamet) 400 mg two times daily or 800 mg at night
Proton pump inhibitors	Treatment duration is four weeks for duodenal ulcer and eight weeks for gastric ulcer 80 to 100 percent healing	Omeprazole 20 mg daily
		Lansoprazole 15 mg daily
		Rabeprazole (Aciphex) 20 mg daily
		Pantoprazole 40 mg daily
Sucralfate (Carafate)	Treatment duration is four weeks blockers Effectiveness similar to H₂	1 g four times daily
Surgery	Rarely needed	Duodenal ulcer: truncal vagotomy, selective vagotomy, highly selective vagotomy, partial gastrectomy
Surgery	Rarely needed	Gastric ulcer: partial gastrectomy with gastroduodenal or gastrojejunal anastomosis