ClassificationRisk factors
Toxic-metabolicAlcohol
Chronic renal failure
Hypercalcemia (hyperparathyroidism)
Hyperlipidemia (rare)
Medications*
Tobacco
Toxins
IdiopathicEarly and late onset
Tropical pancreatitis (tropical calcific pancreatitis and fibrocalculous pancreatic diabetes)
GeneticAutosomal dominant (cationic trypsinogen [codon 29 and 122 mutations])
Autosomal recessive modifier genes (CFTR and SPINK1 mutations, cationic trypsinogen [codon 16, 22, and 23 mutations], alpha 1-antitrypsin deficiency)
AutoimmuneAutoimmune chronic pancreatitis associated with inflammatory bowel disease, Sjögren syndrome, primary biliary cirrhosis
Isolated autoimmune chronic pancreatitis
Recurrent and severe acute pancreatitisPostirradiation
Postnecrotic (severe acute pancreatitis)
Recurrent acute pancreatitis
Vascular ischemia
ObstructivePancreas divisum
Sphincter of Oddi disorders
Duct obstruction (pancreatic or ampullary tumors, posttraumatic pancreatic duct fibrosis)