Key clinical recommendation	Evidence rating	References
IgA tissue transglutaminase antibodies and IgA endomysial antibodies are appropriate first-line serologic tests to rule in celiac disease.	C	5, 6, 16, 17, 20
Because IgA deficiency can cause false-negative results, total IgA levels should be measured in patients at high risk for celiac disease who have negative results on serologic testing.	C	2, 5, 17
Small bowel biopsy should be performed to confirm the diagnosis of celiac disease in patients with abnormal results on serologic testing.	C	2, 5, 6, 16
A gluten-free diet is recommended as the primary treatment for celiac disease.	A	2, 23, 26