Medications	Initial dosage	Goal dosage	Maximum dosage
Noradrenergic drugs
Clonidine (Catapres)	0.05 mg at bedtime	0.1 mg three times daily	0.2 mg three times daily
Guanfacine (Tenex)	0.5 mg at bedtime	1 mg twice daily	1 mg three times daily
Dopamine-receptor–blocking drugs
Fluphenazine (Prolixin—brand no longer available)	0.5 mg at bedtime	1 mg three times daily	3 mg three times daily
Olanzapine (Zyprexa)	1.25 mg at bedtime	2.5 mg twice daily	5 mg twice daily
Pimozide (Orap)	0.5 mg at bedtime	1 mg twice daily	3 mg twice daily
Risperidone (Risperdal)	0.25 mg at bedtime	1 mg twice daily	2 mg twice daily
Dopamine-depleting drugs
Tetrabenazine (investigational)	12.5 mg at bedtime	25 mg three times daily	50 mg three times daily
Other drugs
Baclofen (Lioresal Intrathecal solution for injection—only form of brand available)	5 mg daily	10 mg three times daily	20 mg three times daily
Clonazepam (Klonopin)	0.25 mg at bedtime	0.5 mg three times daily	1 mg three times daily
Topiramate (Topamax)	25 mg at bedtime	100 mg daily	200 mg daily