Clinical recommendation	Evidence rating	References
Antidepressants improve depression symptoms in adults compared with placebo. Among antidepressants, there are not important differences in effectiveness.	A	7, 16
Treat depression at adequate doses of antidepressants for a minimum of four to eight weeks before labeling a treatment regimen ineffective.	C	14
Monitor patients taking antidepressants for side effects, suicidality, and effectiveness.	C	14
Consider a change in therapy if there is no improvement after four to 12 weeks of antidepressant treatment.	B	21
After treatment failure with an antidepressant, the next option may be a different medication of the same class, a medication from a different class, or augmentation with a second agent.	B	14, 21, 27