Type of side effect	SSRIs	SNRIs	Trazodone (Desyrel)*	Bupropion (Wellbutrin)
Cardiovascular	Prolonged QT interval	Elevated blood pressure	Dysrhythmia, hypertension, hypotension	Dysrhythmia, elevated blood pressure, tachycardia
Dermatologic	Rash, sweating	Diaphoresis	Sweating	Itching, rash, Stevens-Johnson syndrome, urticaria
Endocrine metabolic	—	—	Weight gain	Weight loss
Gastrointestinal	Dyspepsia, hemorrhage, loss of appetite, nausea, xerostomia	Constipation or diarrhea, decreased appetite, gastritis, nausea, xerostomia	Constipation, diarrhea, loss of appetite, nausea, vomiting, xerostomia	Constipation, disorder of taste, nausea, pharyngitis, xerostomia
Hematologic	—	—	Hemolytic anemia, leukocytosis, methemoglobinemia	—
Musculoskeletal	—	—	—	Arthralgia, myalgia
Neurologic	Asthenia, insomnia, seizure, somnolence, tremor	Dizziness, fatigue, insomnia, somnolence	Dizziness, headache, insomnia, lethargy, memory impairment, seizure, somnolence	Confusion, dizziness, headache, insomnia, seizure, tinnitus, tremor
Ophthalmic	—	Blurred vision	Blurred vision	—
Psychiatric	Mania/hypomania, suicidal thoughts, suicide, worsening of depression	Suicidal thoughts, suicide, worsening of depression	Suicidal thoughts, suicide, worsening of depression	Agitation, anxiety, hostility, mania, psychosis, suicidal thoughts, worsening of depression
Renal	—	Dysuria	—	—
Reproductive	Abnormal ejaculation, impotence	Abnormal ejaculation, impotence	Priapism	—